List of Publications Using Islets From ICR

  Below is a list of publications representing the work supported, in part, by funding from the National Islet Cell Resource Program. PUBMED Abstracts of the articles are available below. All articles are ordered by year of publication and alphabetically by author's last name.
Asari S, Itakura S, Ferreri K, Liu CP, Kuroda Y, Kandeel F, Mullen Y: Mesenchymal stem cells suppress B-cell terminal differentiation. Exp Hematol. 2009 May; 37(5): 604-15. [PUBMED]
Balamurugan AN, Akhov L, Selvaraj G, Pugazhenthi S: Induction of antioxidant enzymes by curcumin and its analogues in human islets: Implications in transplantation. Pancreas Vol 00, (00) Published Ahead of Print, 2 Feb 2009 [PUBMED]
Chen H, Gu X, Su IH, Bottino R, Contreras JL, Tarakhovsky A, Kim SK: Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes & Dev. 2009 Apr 15; 23(8):975-85 [PUBMED]
Correa-Medina M, Bravo-Egana V, Rosero S, Ricordi C, Edlund H, Diez J, and Pastori RL: MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas. Gene Expr Patterns. 2009 Apr;9 (4):193-9. Epub 2008 Dec 24. [PUBMED]
Dhawan S, Tschen SI, Bhushan A: Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. Genes Dev. 2009 Apr 15;23(8):906-11. [PUBMED]
Fiaschi-Taesch N, Bigatel TA, Sicari B, Takane KK, Salim F, Velazquez-Garcia S, Harb G, Selk K, Cozar-Castellano I, Stewart AF: Survey of the Human Pancreatic Beta Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human Beta Cell Replication and Function in Vivo. Diabetes, 2009 Apr;58(4):882-93. Epub 2009 Jan 9. [PUBMED]
Glas R, Sauter NS, Schulthess FT, Shu L, Oberholzer J, Maedler K: Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival. Diabetologia 2009 Aug;52(8):1579-88. Epub 2009 Apr 25 [PUBMED]
Huang J, Levitsky LL, Rhoads DB: Novel P2 Promoter-Derived HNF4α Isoforms with Different N-Terminus Generated by Alternate Exon Insertion. Exp Cell Res. 2009 Apr 15;315(7):1200-11 [PUBMED]
Ichii H, Ricordi C: Current status of islet cell transplantation. J Hepatobiliary Pancreat Surg. 2009;16(2):101-12. Epub 2008 Dec 26 [PUBMED]
Kaddis J, Olack B, Sowinski J, Cravens J, Contreras J, Niland J. Human Pancreatic Islets and Diabetes Research. JAMA. 2009;301(15):1580-1587 [PUBMED abstract]
Lee SH, Hao E, Savinov AY, Geron I, Strongin AY, Itkin-Ansari P: Human [beta]-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies. Transplantation. 2009 Apr 15;87 (7):983-91 [PUBMED]
Liu H, Remedi MS, Pappan KL, Kwon G, Rohatgi N, Marshall CA, McDaniel ML. Both Glycogen Synthase Kinase-3 (GSK-3) and Mammalian Target of Rapamycin (mTOR) Pathways Contribute to DNA Synthesis, Cell Cycle Progression and Proliferation in Human Islets. 2009 Mar;58(3):663-72. Epub 2008 Dec 10 [PUBMED abstract]
Liu S, Le May C, Wong WP, Ward RD, Clegg DJ, Marcelli M, Korach KS, Mauvais-Jarvis F: Importance of extranuclear estrogen receptor-{alpha} and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes. 2009 Jul 8. [Epub ahead of print] [PUBMED]
Mohammed JS, Wang Y, Harvat TA, Oberholzer J, Eddington DT: Microfluidic device for multimodal characterization of pancreatic islets. Lab Chip. 2009 Jan 7;9(1):97-106. Epub 2008 Oct 21. [PUBMED]
Mulla CM, Geras-Raaka E, Raaka BM, Gershengorn MC: High levels of thyrotropin-releasing hormone receptors activate programmed cell death in human pancreatic precursors. Pancreas 2009 Mar. 38(2)197-202. [PUBMED]
Panakanti R, Mahato RI: Bipartite adenoviral vector encoding hHGF and hIL-1Ra for improved human islet transplantation. Pharm Res. 2009 Mar;26(3):587-96. Epub 2008 Nov 12. [PUBMED]
Panakanti R, Mahato RI: Bipartite Vector Encoding hVEGF and hIL-1Ra for Ex Vivo Transduction into Human Islets. Mol Pharm. 2009 Jan-Feb; 6(1): 274-84. [PUBMED]
Qi M, Barbaro B, Wang S, Wang Y, Hansen M, Oberholzer J: Human pancreatic islet isolation: Part I: digestion and collection of pancreatic tissue. J Vis Exp. 2009 May 26;(27). pii: 1125. doi: 10.3791/1125 [PUBMED]
Qi M, Barbaro B, Wang S, Wang Y, Hansen M, Oberholzer J: Human pancreatic islet isolation: Part II: purification and culture of human islets. J Vis Exp. 2009 May 26;(27). pii: 1343. doi: 10.3791/1343 [PUBMED]
Russ HA, Ravassard P, Kerr-Conte J, Pattou F, Efrat S: Epithelial-mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic Beta cells. PLoS One. 2009 Jul 29;4(7):e6417 [PUBMED]
Sarkar SA, Kutlu B, Velmurugan K, Kizaka-Kondoh S, Lee CE, Wong R, Valentine A, Davidson HW, Hutton JC, Pugazhenthi S: Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-κB) signaling in human islets and in a mouse beta cell line. Diabetologia. 2009 Jun;52(6):1092-101. Epub 2009 Apr 3. [PUBMED]
Schulthess FT, Paroni F, Sauter NS, Shu L, Ribaux P, Haataja L, Strieter RM, Oberholzer J, King CC, Maedler K: CXCL10 impairs β-cell function and viability in diabetes through TLR4 signaling. Cell Metab. 2009 Feb;9(2):125-39. [PUBMED]
Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K: Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet. 2009 Jul 1;18(13):2388-99. Epub 2009 Apr 21 [PUBMED]
Yu J, Steck AK, Babu S, Yu L, Miao D, McFann K, Hutton J, Eisenbarth GS, Klingensmith G. Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes. J Clin Endocrinol Metab. 2009 Feb; 94(2):504-10. Epub 2008 Dec 2. [PUBMED abstract]
Zhang S, Carper MJ, Lei X, Cade WT, Yarasheski KE, Ramanadham S: Protease inhibitors used in the treatmentof HIV induce β-cell apoptosis via the mitochondrial pathway and compromise insulin secretion. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E925-35. Epub 2009 Feb 10 [PUBMED]
Al-Abdullah IH, Bentsi-Barnes K, Valiente L, et al. Testing Combinations of Protease Inhibitor and Preservation Solution to Improve Islet Quality and Yield. Transplantation Proceedings 2008. 40, 390-392. [PUBMED abstract]
Alejandro R, Barton FB, Hering BJ, Wease S; Collaborative Islet Transplant Registry Investigators: 2008 Update from the Collaborative Islet Transplant Registry. Transplantation. 2008 Dec 27;86(12):1783-8 [PUBMED]
Avgoustiniatos ES, Hering BJ, Rozak PR, Wilson JR, Tempelman LA, Balamurugan AN, Welch DP, Weegman BP, Suszynski TM and Papas KK: Commercially available gas-permeable cell culture bags may not prevent anoxia in cultured or shipped islets. Transplant Proc. 2008 Mar;40(2):395-400. [PUBMED abstract]
Bar Y, Russ HA, Knoller S, Ouziel-Yahalom L, Efrat S: HES-1 is involved in adaptation of adult human β-Cells to proliferation in vitro. Diabetes. 2008 Sep;57(9):2413-20. Epub 2008 Jul 3. [PUBMED]
Bentsi-Barnes K, Kandeel F, Al-Abdullah IH. Evaluation of Human Islet- Specific Functional Quality Cultured on Different Gas- Permeable Membranes. Transplantation Proceedings 2008. 40, 401-402. [PUBMED abstract]
Bravo-Egana V, Rosero S, Molano RD, Pileggi A, Ricordi C, Domínguez-Bendala J, Pastori RL: Quantitative differential expression analysis reveals miR-7 as major islet microRNA. Biochem Biophys Res Commun 2008. 366(4):922-6. Epub 2007 Dec 18. [PUBMED abstract]
Brissova M, Powers AC. Revascularization of Transplanted Islets: Can It Be Improved? Diabetes 57: 2269, 2008. [PUBMED abstract]
Brun T, He KH, Lupi R, Boehm B, Wojtusciszyn A, Sauter N, Donath M, Marchetti P, Maedler K, Gauthier BR: The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1. Hum Mol Genet 2008. 17(4):478-89. Epub 2007 Nov 7. [PUBMED abstract]
Cabrera O, Jacques-Silva MC, Speier S, Yang S-N, Kohler M, Fachado A, Vieira E, Zierath JR, Kibbey R, Berman DM, Kenyon NS, Ricordi C, Caicedo A, Berggren PO: Glutamate Is a Positive Autocrine Signal for Glucagon Release. Cell Metab 7, 545-554; Jun 2008. [PUBMED]
Cabrera O, Jacques-Silva MC, Berman DM, Fachado A, Echeverri F, Poo R, Khan A, Kenyon NS, Ricordi C, Berggren PO, Caicedo A: Automated, high-throughput assays for evaluation of human pancreatic islet function. Cell Transplant. 2008;16(10):1039-48. [PUBMED]
Chambers KT, Unverferth JA, Weber SM, Wek RC, Urano F, Corbett JA: The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. Diabetes. 2008 Jan; 57(1):124-32. [PUBMED]
Cheng G, Zhu L, Mahato RI: Caspase-3 Gene Silencing for Inhibiting Apoptosis in Insulinoma Cells and Human Islets. Mol Pharm. 2008 Nov-Dec;5(6):1093-102. [PUBMED]
Cozar-Castellano I, Harb G, Selk K, Takane K, Vasavada R, Sicari B, Law B, Zhang P, Scott DK, Fiaschi-Taesch N, Stewart AF: Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines. Diabetes, 2008 Nov;57(11):3056-68. Epub 2008 Jul 23 [PUBMED]
Deshet N, Lupu-Meiri M, Espinoza I, Fili O, Shapira Y, Lupu R, Gershengorn MC, Oron Y: Plasminogen-induced aggregation of PANC-1 cells requires conversion to plasmin and is inhibited by endogenous plasminogen activator inhibitor-1. J. Cell. Physiol. 216: 632-639. 2008 [Wiley]
Dorrell C, Abraham SL, Lanxon-Cookson KM, Canaday PS, Streeter PR, Grompe M: Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. Stem Cell Res. 2008 Sep;1(3):183-94. Epub 2008 May 8 [PubMed]
Efrat S: Ex-vivo Expansion of Adult Human Pancreatic Beta-Cells. Rev Diabet Stud. 2008 Summer;5(2):116-22. Epub 2008 Aug 10. [PUBMED abstract]
Evgenov NV, Pratt J, Pantazopoulos P, Moore A: Effects of Glucose Toxicity and Islet Purity on In Vivo Magnetic Resonance Imaging of Transplanted Pancreatic Islets. Transplantation 2008;85: 1091-1098. [PUBMED abstract]
Fornoni A, Pileggi A, Molano RD, Sanabria NY, Tejada T, Gonzalez-Quintana J, Ichii H, Inverardi L, Ricordi C, Pastori RL: Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation. Diabetologia 2008 Feb; 51(2): 298-308. Epub Dec 8. [PUBMED]
Gangemi A, Salehi P, Hatipoglu B, Martellotto J, Barbaro B, Kuechle JB, Qi M, Wang Y, Pallan P, Owens C, Bui J, West D, Kaplan B, Benedetti E, Oberholzer J. Islet transplantation for brittle type 1 diabetes: the UIC protocol. Am J Transplant. 2008 Jun;8(6):1250-61. [PUBMED abstract]
Huang J, Karakucuk V, Levitsky LL and Rhoads DB. Expression of HNF4a variants in pancreatic islets and Ins-1 b cells. Diabetes Metab Res Rev 2008 [Epub ahead of print: June 17; DOI: 10.1002/dmrr.870] [PUBMED abstract]
Ichii H, Miki A, Yamamoto T, Molano RD, Barker S, Mita A, Rodriguez-Diaz R, Klein D, Pastori R, Alejandro R, Inverardi L, Pileggi A, Ricordi C: Characterization of pancreatic ductal cells in human islet preparations. Lab Invest. 2008 Sep 8. [Epub ahead of print]  [PUBMED abstract]
Iglesias I, Bentsi-Barnes K, Umeadi C, Brown L, Kandeel F, Al-Abdulla IH. Comprehensive Analysis of Human Pancreatic Islets Using Flow and Laser Scanning Cytometry. Transplantation Proceedings 2008. 40, 351-354 [PUBMED abstract]
Ikonomou L, Geras-Raaka E, Raaka BM, Gershengorn MC. Beta-catenin signaling in mesenchymal islet-derived precursor cells. Cell Proliferation 2008. 41:474. [PUBMED abstract]
Ito T, Omori K, Rawson J, Todorov I, Asari S, Kuroda A, Shintaku J, Itakura S, Ferreri K, Kandeel F, Mullen Y. Improvement of canine islet yield by donor pancreas infusion with a p38MAPK inhibitor. Transplantation. 2008 Jul 27; 86(2): 321-9. [PUBMED abstract]
Jayaraman S: A novel method for the detection of viable human pancreatic beta cells by flow cytometry using fluorophores that selectively detect labile zinc, mitochondrial membrane potential and protein thiols. Cytometry A. 2008 Jul;73(7):615-25.PMID: 18412218 [PUBMED]
Jewell JL, Luo W, Oh E, Wang Z, Thurmond DC. Filamentous actin regulates insulin exocytosis through direct interaction with Syntaxin 4. J Biol Chem 2008. 283:10716-10726. PMID: 18285343 [Full text]
Juhl K, Sarkar SA, Wong R, Jensen J, Hutton JC: The mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3 null mouse. Diabetes. 2008 Jul 3. [PUBMED abstract]
Kang G, Leech CA, Chepurny OG, Coetzee WA, Holz GG: Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells. J Physiol 2008. 586(5):1307-19. Epub 2008 Jan 17. [PUBMED abstract]
King M, Pearson T, Rossini AA, Shultz LD, Greiner DL: Humanized mice for the study of type 1 diabetes and beta cell function. Ann NY Acad Sci 2008 Dec; 1150: 46-53 [PUBMED]
King MT, Pearson LD, Shultz JL, Bottino M, Trucco, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL 2 receptor gamma chain gene. Clinical Immunology 2008. 126:303-314. [PUBMED abstract]
Klein D, Timoneri F, Ichii H, Ricordi C, Pastori RL. CD40 Activation in Human Pancreatic Islets and Ductal Cells. Diabetologia. 2008 Jul 26. [PUBMED abstract]
Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD. Overexpression of pre-pro-cholecystokinin stimulates {beta}-cell proliferation in mouse and human islets with retention of islet function. Mol Endocrinol. 2008 Oct 9. [PUBMED abstract]
Lee S-H, Demeterco C, Geron I, Abrahamsson A, Levine F, Itkin-Ansari P: Islet specific Wnt activation in human type II diabetes. Exp Diabetes Res. 2008; 728-763. [PUBMED]
Leitao CB, Tharavanij T, Cure P, Pileggi A, Baidal DA, Ricordi C, Alejandro R. Restoration of Hypoglycemia Awareness after Islet Transplantation. Diabetes Care. 2008 Aug 12. [PUBMED abstract]
Li F, Mahato RI: iNOS gene silencing prevents inflammatory cytokine-induced beta-cell apoptosis. Mol Pharm 2008 May-Jun;5(3):407-17. Epub 2008 Jan 25. [PUBMED abstract]
Li N, Zhao D, Kirschbaum M, Zhang C, Lin CL, Todorov I, Kandeel F, Forman S, Zeng D. HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen. Proc Natl Acad Sci U S A 105, 4796-4801, 2008. [PUBMED abstract]
Li Y, Maedler K, Shu L, Haataja L. UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells. PLoS ONE. 2008 Jan 2; 3(1):e1397. [PUBMED abstract]
Linetsky E, Ricordi C. Regulatory challenges in manufacturing of pancreatic islets. Transplant Proc. 2008 Mar;40(2):424-6. [PUBMED abstract]
Luo L, Fang X, Ricordi C, Luo J: Human Islet Longevity: A New Approach with Allogeneic Bone Marrow. 2008 Diabetes 57:Suppl.1 1596-P, A446
Marselli L, Thorne J, Ahn YB, Omer A, Sgroi DC, Libermann T, Otu HH, Sharma A, Bonner-Weir S, Weir GC. Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab. 2008 Mar;93(3):1046-53. [PUBMED abstract]
Mathew JM, Blomberg B, Ricordi C, Esquenazi V, Miller J. Evaluation of the tolerogenic effects of donor bone marrow cells using a severe combined immunodeficient mouse-human islet transplant model. Hum Immunol. 2008 Aug 11 [Epub ahead of print]. [PUBMED abstract]
Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Maedler K, Allayee H. Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia. 2008 Jun;51(6):978-88. [PUBMED abstract]
Miki A, Ricordi C, Yamamoto T, Mita A, Barker S, Khan A, Alejandro R, Ichii H: Effect of Human Islet Rescue Gradient Purification on Islet Yield and Fractional Beta Cell Viability. Transplant Proc. 2008 Mar;40(2):360-1. [PUBMED abstract]
Parnaud G, Bosco D, Berney T, Pattou F, Kerr-Conte J, Donath MY, Bruun C, Mandrup-Poulsen T, Billestrup N, Halban PA. Proliferation of sorted human and rat beta cells. Diabetologia. 2008 Jan;51(1):91-100. [PUBMED abstract]
Pearson T, Shultz LD, Leif J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL: A new immunodeficient hyperglycemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia. 2008 Aug;51(8):1449-56. Epub 2008 Jun 19. [PUBMED abstract]
Poitout V, Robertson RP. Glucolipotoxicity: Fuel excess and beta-cell dysfunction. Endocr Rev 2008. 29(3):351-66. Epub 2007 Nov 29 [PUBMED abstract]
Powers AC. Insulin Therapy versus Cell-Based Therapy for Type 1 Diabetes - What is ahead? Nature Clinical Practice Endocrinology & Metabolism, in press, 2008 [PUBMED abstract]
Robertson RP. Metabolic measures of islet function and mass after islet transplantation. In. Islet transplantation and beta-cell replacement therapy. Eds. Shaw J, Ricordi C, Lakey J, Shapiro J. In press.
Robertson RP. Beta-cell replacement: pancreas and islet transplantation. In Type 1 diabetes in adults: principle and practice. Eds. Jabbour S, Hirsch I, Garg S, Stephens EZ, Goldstein BJ, Riddle M. 2008 In press
Rozak PR, Weegman B, Avgoustiniatos ES, Wilson JR, Welch DP, Hering BJ, Papas KK: Devices and methods for maintenance of temperature and pressure during islet shipment. Transplant Proc. 2008 Mar;40(2):407-10. [PUBMED abstract]
Sakuma Y, Ricordi C, Miki A, Yamamoto T, Pileggi A, Khan A, Alejandro R, Inverardi L, Ichii H: Factors That Affect Human Islet Isolation. Transplant Proc. 2008 Mar;40(2):343-5. [PUBMED abstract]
Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K. Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes. 2008 Mar;57(3):645-53. Epub 2007 Dec 10. PMID: 18071026 Full Text Diabetes
Stanojevic V, Habener JF, Holz GG, Leech CA: Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells. Biochem Biophys Res Commun 2008. 368(3):614-9. Epub 2008 Feb 1. [PUBMED abstract]
Suckow AT, Comoletti D, Waldrop MA, Mosedale M, Egodage S, Taylor P, Chessler SD. Expression of neurexin, neuroligin and their cytoplasmic binding partners in the pancreatic {beta}-cells and the involvement of neuroligin in insulin secretion. Endocrinology 149 (12): 6006-6017, Dec. 2008 [PUBMED abstract]
Suszynski TM, Wildey GM, Falde EJ, Cline GW, Maynard KS, Ko N, Sotiris J, Naji A, Hering BJ, Papas KK: The ATP/DNA Ratio Is a Better Indicator of Islet Cell Viability Than the ADP/ATP Ratio. Transplant Proc. 2008 Mar;40(2):346-50. [PUBMED abstract]
Sweet IR, Gilbert M, Scott S, Todorov I, Jensen R, Nair I, Al-Abdullah I, Rawson J, Kandeel F, Ferreri K: Glucose-stimulated increment in oxygen consumption rate as a standardized test of human islet quality. Am J Transplant. 2008 Jan;8(1):183-92. Epub 2007 Nov 12. [PUBMED abstract]
Umeadi C, Bentsi-Barnes K, Kandeel F, Al-Abdullah IH. Endogenous Pancreatic Protease Activity and Methods for Impeding Their Function. Transplantation Proceedings 2008. 40, 355-357 [PUBMED abstract]
Umeadi C, Kandeel F, Al-Abdullah IH: Ulinastatin Is a Novel Protease Inhibitor and Neutral Protease Activator. Transplant Proc. 2008 Mar;40(2):387-9. [PUBMED]>
Varona-Santos JL, Pileggi A, Molano RD, Sanabria NY, Ijaz A, Atsushi M, Ichii H, Pastori RL, Inverardi L, Ricordi C, Fornoni A. c-Jun N-terminal kinase 1 is deleterious to the function and survival of murine pancreatic islets. Diabetologia. 2008 Dec;51(12):2271-80. Epub 2008 Oct 14. [PUBMED abstract]
Vlad G, D'Agati VD, Zhang QY, Liu Z, Ho EK, Mohanakumar T, Hardy MA, Cortesini R, Suciu-Foca N. ILT3-FC Suppresses T Cell Responses to Allogeneic Human Islet Transplants in HU-NOD/SCID Mice. Diabetes 2008; Apr 16. [Epub ahead of print] PMID: 18420485 [PUBMED abstract]
Xu BY, Yu Y, Al-Abdullah IH, Kandeel F, Hering B, Wright Jr. JR: Long-Term Survival and Function of Intraportal Porcine and Human Islet Xenografts in Nondiabetic Nude Mice. Transplant Proc. 2008 Mar; 40(2):584-6. PMID: 18374135 [PUBMED]
Yamamoto T, Ricordi C, Mita A, Miki A, Sakuma Y, Molano RD, Fornoni A, Pileggi A, Inverardi L, Ichii H: Beta-Cell Specific Cytoprotection by Prolactin on Human Islets. Transplant Proc. 2008 Mar;40(2):382-3. [PUBMED abstract]
Ai C, Todorov I, Slovak ML, Digiusto D, Forman SJ, Shih CC. Human Marrow-Derived Mesodermal Progenitor Cells Generate Insulin-Secreting Islet-Like Clusters In Vivo. Stem Cells Dev 16, 757-770, 2007. [PUBMED abstract]
Barbaro B, Salehi P, Wang Y; Qi M, Gangemi A, Kuechle J, Hansen MA, Romagnoli T, Avila J, Benedetti E, Mage R, Oberholzer J: Improved Human Pancreatic Islet Purification With the Refined UIC-UB Density Gradient. Transplantation. 84(9):1200-1203, November 15, 2007. [PUBMED abstract]
Barnett BP, Arepally A, Karmarkar PV, Qian D, Gilson WD, Walczak P, Howland V, Lawler L, Lauzon C, Stuber M, Kraitchman DL, Bulte JW. Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells. Nat Med. 2007 Sep;13(8):986-991. Epub 2007 Jul 29.[PUBMED abstract]
Bertuzzi F, Ricordi C: Prediction of clinical outcome in islet allotransplantation. Diabetes Care. 2007 Feb;30(2):410-7. [PUBMED abstract]
Chow R, Michael D, Xiong W, Drain P: Pulsatile Insulin Secretion Imaged at the Single-Vesicle Level in Human Pancreatic Beta Cells. Microscopy and Microanalysis 13 (Suppl 2): 322-323. Aug 2007. [ProQuest abstract]
Clark GO, Yochem RL, Axelman J, Sheets TP, Kaczorowski DJ, Shamblott MJ: Glucose responsive insulin production from human embryonic germ (EG) cell derivatives. Biochem Biophys Res Commun. 2007 May 11;356(3):587-93. [PUBMED abstract]
Davani B, Ikonomou L, Raaka BM, Geras-Raaks E, Morton RA, Marcus-Samuels B, Gershengorn MC. Human islet-derived precursor cells are mesenchymal stromal cells that differentiate and mature to hormone-expressing cells in vivo. Stem Cells 2007. 25:3215. PMID: 17901402 Full Text - Stem Cells
De Paula D, Bentley MV, Mahato RI: Effect of iNOS and NF-kappaB gene silencing on beta-cell survival and function. J Drug Target. 2007 Jun;15(5):358-69. [PUBMED abstract]
Faradji RN, Monroy K, Messinger S, Pileggi A, Froud T, Baidal DA, Cure PE, Ricordi C, Luzi L, Alejandro R. Simple measures to monitor beta-cell mass and assess islet graft dysfunction. Am J Transplant. 2007 Feb;7(2): 303-8. Epub 2006 Dec 6.[PUBMED abstract]
Fisher JS, Lakey JRT, Mirbolooki M, Robertson RP, Marsh CL. Pancreas and Islet Transplantation. In: Comprehensive Clinical Nephrology, 3rd Edition, p. 1131-1145. eds Feehally, J, Floege J, Johnson RJ, 2007.
Ichii H, Wang X, Messinger S, Alvarez A, Fraker C, Khan A, Kuroda Y, Inverardi L, Goss JA, Alejandro R, Ricordi C. Shipment of human islets for transplantation. Am J Transplant. 2007 Apr;7(4):1010-20. [PUBMED abstract]
Itakura S, Asari S, Rawson J, Ito T, Todorov I, Liu CP, Sasaki N, Kandeel F, Mullen Y: Mesenchymal stem cells facilitate the induction of mixed hematopoietic chimerism and islet allograft tolerance without GVHD in the rat. Am J Transplant 2007 Feb;7 (2):336-46. PMID: 17283484 [PUBMED]
Jia X, Cheng K, Mahato RI. Coexpression of vascular endothelial growth factor and interleukin-1 receptor antagonist for improved human islet survival and function. Mol Pharm 2007. Mar-Apr;4(2);199-207. [PUBMED abstract]
Kayali AG, Flores LE, Lopez AD, Kutlu B, Baetge E, Kitamura R, Hao E, Beattie GM, Hayek A. Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing beta-cells. Diabetes. 2007 Mar;56(3):703-8. [PUBMED abstract]
Ke B, Oh E, Thurmond DC. Doc2beta is a novel Munc18c- interacting partner and positive effector of syntaxin 4-mediated exocytosis. J Biol Chem. 2007 Jun 4. [PUBMED abstract]
Luo L, Badiavas E, Colvin G, Luo J, Maizel A: Allogeneic Bone Marrow Support Of Human Pancreatic Islet's β-Cells. Biochem Biophys Res Commun. Volume 361, Issue 4, 5 Oct 2007, Pages 859-864. PMID: 17686461
Michael DJ, Xiong W, Geng X, Drain P, Chow RH: Human insulin vesicle dynamics during pulsatile secretion. Diabetes. 2007 May;56(5):1277-88. [PUBMED abstract]
Mutskov V, Raaka BM, Felsenfeld G, Gershengorn MC. The Human Insulin Gene Displays Transcriptionally Active Epigenetic Marks in Islet-derived Mesenchymal Precursor Cells in the Absence of Insulin Expression. Stem Cells 2007 Sep 27; [PUBMED abstract]
Omori K, Shintaku J, Rawson J, Todorov I, Nair I, Al-Abdullah I, Higgins LS, Medicherla S, Kandeel F, Mullen Y. P38 mitogen activated protein kinase inhibitor (p38IH) improved the quality of cultured human islets. Xenotransplantation, Volume 14, Issue 5 (p 420).
Omori K, Valiente L, Orr C, Rawson J, Ferreri K, Todorov I, Al-Abdullah I, Medicherla S, Potter AA, Shreiner GF, Kandeel F, Mullen Y: Improvement of human islet cryopreservation by a p38 MAPK inhibitor. Am J Transplant 7:1224-1232, May 2007 [PUBMED abstract]
Papas KK, Colton CK, Nelson RA, Rozak PR, Avgoustiniatos ES, Scott WE 3rd, Wildey GM, Pisania A, Weir GC, Hering BJ. Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice. Am J Transplant. 2007 Mar;7(3):707-13. Epub 2007 Jan 4. [PUBMED abstract]
Pissios P, Ozcan U, Kokkotou E, Okada T, Liew CW, Liu S, Peters JN, Dahlgren G, Karamchandani J, Kudva YC, Kurpad AJ, Kennedy RT, Maratos-Flier E, Kulkarni RN. Melanin Concentrating Hormone Is a Novel Regulator of Islet Function and Growth. Diabetes 56(2):311-9, 2007. [PUBMED abstract]
Qian D, Kaddis J, Niland J. A matching algorithm for the distribution of human pancreatic islets. Comput. Statist. Data Anal. (2007), doi: 10.1013/j.csda.2007.02.030 [PUBMED abstract]
Rawson J, Kandeel F, Mullen Y: Evaluation of three mouse models for in vivo quality assessment of human islets: euglycemic NOD scid, multidoes- STZ diabetic NOD scid and AKITA rag-/- mice. Xenotransplantation, Volume 14, Issue 5 (p 500).
Rickels MR, Kamoun M, Kearns J, Markmann JF, Naji A. Evidence for Allograft Rejection in an Islet Transplant Recipient and Effect on {beta}-Cell Secretory Capacity. J Clin Endocrinol Metab. 2007 Jul;92(7):2410-4. Epub 2007 May 8. [PUBMED abstract]
Rickels MR, Schutta MH, Mueller R, Kapoor S, Markmann JF, Naji A, Teff KL. Glycemic thresholds for activation of counterregulatory hormone and symptom responses in islet transplant recipients. J Clin Endocrinol Metab. 2007 Mar;92(3):873-9. Epub 2006 Dec 27. [PUBMED abstract]
Ritzel RA, Meier JJ, Lin CY, Veldhuis JD, Butler PC. Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets. Diabetes. 2007 Jan;56(1):65-71. [PUBMED abstract]
Robertson RP. Estimation of beta-cell mass by metabolic tests: necessary, but how sufficient? Diabetes. 2007 Oct;56(10):2420-4. Epub 2007 Jul 2. Full Text - Diabetes
Robertson, RP. Beta Cell Replacement: Pancreas and Islet Transplantation. Type 1 Diabetes in Adults: Principles and Practice. p. 247-261. Jabbour S, Stephens EA, Hirsch I, Goldstein BJ, Garg S, Riddle M, eds. Informa Healthcare, plc. 2007.
Robertson RP, Sutherland DER. Beta and alpha cell metabolic outcomes after successful pancreas and islet transplantation at the University of Minnesota. Clin Transpl 2007.
Sarkar SA, Gunter J, Bouchard R, Reusch JE, Wiseman A, Gill RG, Hutton JC, Pugazhenthi S. Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets. Diabetologia. 2007 Aug;50(8):1649-59. Epub 2007 Jun 26. [PUBMED abstract]
Sarkar SA, Wong R, Hackl SI, Moua O, Gill RG, Wiseman A, Davidson HW, Hutton JC. Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets. Diabetes 2007 Jan. 56(1):72-9. [PUBMED abstract]
Todorov I, Nair I, Omori K, Ito T, Rawson J, Valiente L, Al-Abdullah I, Ferreri K, Mullen Y, Kandeel F: Evaluation of cell composition and beta cell apoptosis in isolated undissociated pancreatic islets by laser scanning cytometry. Xenotransplantation, Volume 14, Issue 5 (p 499).
Tonooka N, Oseid E, Zhou H, Harmon J, Robertson RP. Glutathione peroxidase protein expression and activity in human islets isolated for transplantation. Clin Transplant 21:767-772, 2007. [PUBMED abstract]
Tracy S, Drescher KM. Coxsackievirus infections and NOD mice: relevant models of protection from, and induction of, type 1 diabetes. Ann N Y Acad Sci. 2007 Apr;1103:143-51. Epub 2007 Mar 21. Review. [PUBMED abstract]
Vasavada RC, Wang L, Fujinaka Y, Takane KK, Rosa TC, Mellado-Gil JM, Friedman PA, Garcia-Ocana A. Protein Kinase C-{zeta} Activation Markedly Enhances {beta}-Cell Proliferation: An Essential Role in Growth Factor-Mediated {beta}-Cell Mitogenesis. Diabetes. 2007 Aug 8; [Epub ahead of print] [PUBMED abstract]
Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, Rewers M, Eisenbarth GS, Jensen J, Davidson HW, Hutton JC: The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5. [PUBMED abstract]
Yamamoto T, Ricordi C, Messinger S, et al: Deterioration and Variability of Highly Purified Collagenase Blends Used in Clinical Islet Isolation. Transplantation 2007. Volume 84(8), 27 October 2007, pp 997-1002. [PUBMED abstract]
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Barbé-Tuana FM, Klein D, Ichii H, Berman DM, Coffey L, Kenyon NS, Ricordi C, Pastori RL: CD40–CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets. Diabetes 55:2437-2445, 2006 [PUBMED abstract]
Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A: The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc.Natl.Acad.Sci.U.S.A 103:2334-2339, 2006 [PUBMED abstract]
Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, Takane KK, Garcia-Ocana A, Vasavada R, Stewart AF. Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev. 2006 Jun;27(4):356-70. Epub 2006 Apr 25. Review. [PUBMED abstract]
Evgenov NV, Medarova Z, Dai G, Bonner-Weir S, Moore A. In vivo imaging of islet transplantation. Nat Med. 2006 Jan;12(1):144-8. Epub 2005 Dec 25. [PUBMED abstract]
  131. Evgenov NV, Medarova Z, Pratt J, Pantazopoulos P, Leyting S, Bonner-Weir S, Moore A: In Vivo Imaging of Immune Rejection in Transplanted Pancreatic Islets. Diabetes 55: 2419-2428, 2006 [PUBMED abstract]
Gianani R, Putnam A, Still T, Yu L, Miao D, Gill RG, Beilke J, Supon P, Valentine A, Iveson A, Dunn S, Eisenbarth GS, Hutton J, Gottlieb P, Wiseman A: Initial results of screening of non - diabetic organ donors for expression of islet autoantibodies. J.Clin.Endocrinol.Metab 2006 May 91 (5):1855-61 Epub 2006 Feb 14. [PUBMED abstract]
Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F. Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas. Nat Med. 2006 Mar;12(3):310-6. Epub 2006 Feb 19. [PUBMED abstract]
Ichii H, Wang X, Messinger S, Alvarez A, Fraker C, Khan A, Kuroda Y, Inverardi L, Goss JA, Alejandro R, Ricordi C. Improved human islet isolation using nicotinamide. Am J Transplant. 2006 Sep;6(9):2060-8. Epub 2006 Jul 6. [PUBMED abstract]
Ihm SH, Matsumoto I, Sawada T, Nakano M, Zhang HJ, Ansite JD, Sutherland DE, Hering BJ. Effect of donor age on function of isolated human islets. Diabetes 2006 May;55(5):1361-8. [PUBMED abstract]
Kaido T, Yebra M, Cirulli V, Rhodes C, Diaferia G, Montgomery AM. Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription. Diabetes 2006 Oct;55(10):2723-9. [PUBMED abstract]
Kang G, Chepurney OG, Malester B, Rindler MJ, Relumann H, Bos JL, Schwede F, Coetzee WA, Holz GG: cAMP Sensor Epac As A Determinant of ATP-Sensitive Potassium Channel Activity in Human Pancreatic Beta Cells And Rat INS-1 Cells. J Physiol 573.3: 595-609, 2006 [PUBMED abstract]
  138. Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Stout DB, Campbell-Thompson M, Atkinson MA, Phelps M, Gambhir SS, Tian J, Kaufman DL: Noninvasive imaging of islet grafts using positron-emission tomography. PNAS 103: 11294-11299, 2006 [PUBMED abstract]
Lu Y, Dang H, Middleton B, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL. Long-term monitoring of transplanted islets using positron emission tomography. Mol Ther. 2006 Dec;14(6):851-6. Epub 2006 Sep 18. [PUBMED abstract]
Medarova Z, Evgenov NV, Dai G, Bonner-Weir S, Moore A. In vivo multimodal imaging of transplanted pancreatic islets. Nat Protoc. 2006;1(1):429-35. [PUBMED abstract]
Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC. Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1317-24. Epub 2006 Jul 18. [PUBMED abstract]
Meier JJ, Ritzel RA, Maedler K, Gurlo T, Butler PC. Increased vulnerability of newly forming beta cells to cytokine-induced cell death. Diabetologia. 2006 Jan;49(1):83-9. Epub 2005 Dec 2. [PUBMED abstract]
Metz TO, Jacobs JM, Gritsenko MA, Fontes G, Qian WJ, Camp DG 2nd, Poitout V, Smith RD. Characterization of the human pancreatic islet proteome by two-dimensional LC/MS/MS. J Proteome Res. 2006 Dec;5(12):3345-54. [PUBMED abstract]
Michael DJ, Ritzel RA, Haataja L, Chow RH: Pancreatic {beta}-Cells Secrete Insulin in Fast- and Slow-Release Forms. Diabetes 55: 600-607, 2006 [PUBMED]
  145. Mohanakumar T, Narayanan K, Desai N, Ramachandran S, Shenoy S, Jendrisak M, Susskind BM, Olack B, Benshoff N, Phelan DL, Brennan DC, Fernandez LA, Odorico JS, Polonsky KS: A significant role for histocompatibility in human islet transplantation. Transplantation Jul 27;82(2):180-7, 2006 [PUBMED abstract]
Narang AS, Sabek O, Gaber AO, Mahato RI: Co-expression of vascular endothelial growth factor and interleukin-1 receptor antagonist improves human islet survival and function. Pharm Res. 2006 Sep;23(9):1970-82. Epub 2006 Aug 12. [PUBMED abstract]
Ouziel-Yahalom L, Zalzman M, Anker-Kitai L, Knoller S, Bar Y, Glandt M, Herold K, Efrat S. Expansion and redifferentiation of adult human pancreatic islet cells. Biochem Biophys Res Commun. 2006 Mar 10;341(2):291-8. Epub 2006 Jan 19. [PUBMED abstract]
Poggioli R, Faradji RN, Ponte G, Betancourt A, Messinger S, Baidal DA, Froud T, Ricordi C, Alejandro R: Quality of life after islet transplantation. Am.J.Transplant 6:371-378, 2006 [PUBMED abstract]
  149. Rickels MR, Naji A, Teff KL: Insulin Sensitivity, Glucose Effectiveness, and Free Fatty Acid Dynamics after Human Islet Transplantation for Type 1 Diabetes. J. Clin. Endocrinol. Metab. 91: 2138-2144, 2006 [PUBMED abstract]
Ritzel RA, Veldhuis JD, Butler PC. The mass, but not the frequency, of insulin secretory bursts in isolated human islets is entrained by oscillatory glucose exposure. Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E750-6. Epub 2005 Nov 8. [PUBMED abstract]
Robertson RP, Harmon JS. Diabetes, glucose toxicity, and oxidative stress: a case of double jeopardy for the pancreatic beta cell. Free Rad Biol Med 2006 Jul 15; 41(2):177-84. [PUBMED abstract]
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Sabek OM, Marshall DR, Penmetsa R, Scarborough O, Gaber AO. Examination of gene expression profile of functional human pancreatic islets after 2-week culture. Transplant Proc. 2006 Dec;38(10):3678-9. [PUBMED abstract]
Scacheri PC, Davis S, Odom DT, Crawford GE, Perkins S, Halawi MJ, Agarwal SK, Marx SJ, Spiegel AM, Meltzer PS, Collins FS. Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLoS Genet 2006 Apr;2(4):e51. Epub 2006 Apr 7 [PUBMED abstract]
Shanmugam N, Todorov IT, Nair I, Omori K, Reddy MA, Natarajan R. Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced glycation endproduct-specific receptor (AGER), and in islets from diabetic mice. Diabetologia. 2006 Jan;49(1):100-7. Epub 2005 Dec 10. [PUBMED abstract]
Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR. International Multicenter Trial of Islet Transplantation in Type 1 Diabetes Using the Edmonton Protocol. N Engl J Med 355(13):1318-30. 2006. [PUBMED abstract]
Steer SA, Scarim AL, Chambers KT, Corbett JA. Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1. PLoS Med 2006 Feb;3(2):e17. Epub 2005 Dec 20. [PUBMED abstract]
Todorov I, Omori K, Pascual M, Rawson J, Nair I, Valiente L, Vuong T, Matsuda T, Orr C, Ferreri K, Smith CV, Kandeel F, Mullen Y. Generation of human islets through expansion and differentiation of non-islet pancreatic cells discarded (pancreatic discard) after islet isolation. Pancreas 2006 Mar;32(2):130-8. [PUBMED abstract]
Yang J, Wong RK, Park M, Wu J, Cook JR, York DA, Deng S, Markmann J, Naji A, Wolf BA, Gao Z: Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells. Diabetes 55:193-201, 2006 [PUBMED abstract]


Zhang G, Matsumoto S, Newman H, Strong DM, Robertson RP, Reems JA. Improve islet yields and quality when clinical grade pancreata are preserved by the two-layer method. Cell Tissue Bank 2006;7(3):195-201. [PUBMED abstract]


Albisser AM, Alejandro R, Meneghini LF, Ricordi C: How good is your glucose control? Diabetes Technol.Ther. 7:863-875, 2005 [PUBMED abstract]
Albisser AM, Baidal D, Alejandro R, Ricordi C: Home blood glucose prediction: clinical feasibility and validation in islet cell transplantation candidates. Diabetologia 2005 Jul;48(7):1273-9. Epub 2005 Jun 3. [PUBMED abstract]
Bharat A, Benshoff N, Olack B, Ramachandran S, Desai NM, Mohanakumar T: Novel in vivo murine model to study islet potency: engraftment and function. Transplantation 79:1627-1630, 2005 [PUBMED abstract]
  166. Brissova M, Fowler MJ, Nicholson WE, Chu A, Hirshberg B, Harlan DM, Powers AC: Assessment of Human Pancreatic Islet Architecture and Composition by Laser Scanning Confocal Microscopy. J. Histochem. Cytochem 53: 1087-1097, 2005 [PUBMED abstract]
Faradji RN, Monroy K, Cure P, Froud T, Baidal D, Pileggi A, Messinger S, Ricordi C, Alejandro R: C-peptide and glucose values in the peritransplant period after intraportal islet infusions in type 1 diabetes. Transplant Proc. 37:3433-3434, 2005 [PUBMED abstract]
  168. Fowler M, Virostko J, Chen Z, Poffenberger G, Radhika A, Brissova M, Shiota M, Nicholson WE, Shi Y, Hirshberg B, Harlan DM, Jansen ED, Powers AC. Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging. Transplantation 2005 Apr 15;79(7):768-76 [PUBMED Abstract]
  169. Fraga DW, Gaber AO, Kotb M: Long-term culture and maintenance of human islets of Langerhans in memphis serum-free media. Methods Mol.Med. 107:303-311, 2005 [PUBMED Abstract]
Froud T, Ricordi C, Baidal DA, Hafiz MM, Ponte G, Cure P, Pileggi A, Poggioli R, Ichii H, Khan A, Ferreira JV, Pugliese A, Esquenazi VV, Kenyon NS, Alejandro R: Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. Am.J.Transplant 5:2037-2046, 2005 [PUBMED abstract]
Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H, Shimomura I, Miyagawa J, Wollheim CB, Yamagata K: The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab 2:373-384, 2005 [PUBMED abstract]
  172. Geiger MC, Ferreira JV, Hafiz MM, Froud T, Baidal DA, Meneghini LF, Ricordi C, Alejandro R: Evaluation of metabolic control using a continuous subcutaneous glucose monitoring system in patients with type 1 diabetes mellitus who achieved insulin independence after islet cell transplantation. Cell Transplant 14:77-84, 2005 [PUBMED Abstract]
Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR: Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 122:337-349, 2005 [PUBMED abstract]
Hafiz MM, Faradji RN, Froud T, Pileggi A, Baidal DA, Cure P, Ponte G, Poggioli R, Cornejo A, Messinger S, Ricordi C, Alejandro R: Immunosuppression and procedure-related complications in 26 patients with type 1 diabetes mellitus receiving allogeneic islet cell transplantation. Transplantation 80:1718-1728, 2005 [PUBMED abstract]
Han D, Leith J, Alejandro R, Bolton W, Ricordi C, Kenyon NS: Peripheral blood cytotoxic lymphocyte gene transcript levels differ in patients with long-term type 1 diabetes compared to normal controls. Cell Transplant 14:403-409, 2005 [PUBMED abstract]
  176. Hering BJ: Achieving and maintaining insulin independence in human islet transplant recipients. Transplantation 79:1296-1297, 2005 [PUBMED Abstract]
  177. Hering BJ, Kandaswamy R, Ansite JD, Eckman PM, Nakano M, Sawada T, Matsumoto I, Ihm SH, Zhang HJ, Parkey J, Hunter DW, Sutherland DE: Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes. JAMA 293:830-835, 2005 [PUBMED Abstract]
Ichii H, Inverardi L, Pileggi A, Molano RD, Cabrera O, Caicedo A, Messinger S, Kuroda Y, Berggren PO, Ricordi C: A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations. Am.J.Transplant 5:1635-1645, 2005 [PUBMED abstract]
  179. Ichii H, Pileggi A, Molano RD, Baidal DA, Khan A, Kuroda Y, Inverardi L, Goss JA, Alejandro R, Ricordi C: Rescue purification maximizes the use of human islet preparations for transplantation. Am.J.Transplant 5:21-30, 2005 [PUBMED Abstract]
Ichii H, Pileggi A, Wang X, Khan A, Kuroda Y, Inverardi L, Alejandro R, Ricordi C: Pre-transplant assessment of cultured islets prior to clinical islet transplantation. American Journal of Transplantation. 5 (S11):790;2005
Jacobson PA, Green KG, Hering BJ: Mycophenolate mofetil in islet cell transplant: variable pharmacokinetics but good correlation between total and unbound concentrations. J.Clin.Pharmacol. 45:901-909, 2005 [PUBMED abstract]
Klein D, Barbe-Tuana F, Pugliese A, Ichii H, Garza D, Gonzalez M, Molano RD, Ricordi C, Pastori RL. A functional CD40 receptor is expressed in pancreatic beta cells. Diabetologia. 2005 Feb;48(2):268-76. Epub 2005 Feb 3. [PUBMED abstract]
  183. Lechner A, Nolan AL, Blacken RA, Habener JF. Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue. Biochem Biophys Res Commun 2005 Feb 11;327(2):581-8 [PUBMED Abstract]
Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC.: Activation of peroxisome proliferator-activated receptors-gamma (PPAR-gamma) by rosiglitazone protects human islet cells against human-islet amyloid polypeptide toxicity by a PI3 kinase-dependent pathway. J Clin Endocrinol Metab. 2005 Dec;90(12):6678-86. Epub 2005 Oct 4. [PUBMED abstract]
  185. Marshall D, Sabek O, Fraga D, Kotb M, Gaber AO: Examination of the molecular signature associated with islet dysfunction. Transplant Proc. 37:1311-1312, 2005 [PUBMED Abstract]
  186. Matsuda T, Omori K, Vuong T, Pascual M, Valiente L, Ferreri K, Todorov I, Kuroda Y, Smith CV, Kandeel F, Mullen Y. Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function. Am J Transplant 2005 Mar;5(3):484-93 [PUBMED Abstract]
Matsuda T, Ferreri K, Todorov I, Duroda Y, Smith CV, Kandeel F, Mullen: Silymarin Protects Pancreatic ß-Cells against Cytokine-Mediated Toxicity: Implication of c-Jun NH2-Terminal Kinase and Janus Kinase/Signal Transducer and Activator of Transcription Pathways. Endocrinology 146: 175-185 Jan 2005 [PUBMED]
  188. Mendoza V, Klein D, Ichii H, Ribeiro MM, Ricordi C, Hankeln T, Burmester T, Pastori RL: Protection of islets in culture by delivery of oxygen binding neuroglobin via protein transduction. Transplant Proc. 37:237-240, 2005 [PUBMED Abstract]
Narang AS, Thoma L, Miller DD, Mahato RI: Cationic lipids with increased DNA binding affinity for nonviral gene transfer in dividing and nondividing cells. Bioconjug Chem. 2005 Jan-Feb;16(1):156-68. [PUBMED]
Nath DS, Hering BJ: Islet cells replacement therapy. Clin.Lab Med. 2005 Sep; 25(3):541-56 [PUBMED abstract]
Omori K, Valiente L, Orr C, Rawson J, Ferreri K, Todorov I, Medicherla S, Protter AA, Schreiner GF, Riggs AD, Kandeel F, Mullen Y. Inhibition of p38 mitogen-activated protein kinase protects human islets from cryoinjury and improves the yield, viability, and quality of frozen-thawed islets. Transplant Proc. 2005 Oct;37(8):3422-3.[PUBMED abstract]
Papas KK, Avgoustiniatos ES, Tempelman LA, Weir GC, Colton CK, Pisania A, Rappel MJ, Friberg AS, Bauer AC, Hering BJ: High-density culture of human islets on top of silicone rubber membranes. Transplant Proc. 37:3412-3414, 2005 [PUBMED abstract]
Papas KK, Hering BJ, Gunther L, Rappel MJ, Colton CK, Avgoustiniatos ES: Pancreas oxygenation is limited during preservation with the two-layer method. Transplant Proc. 37:3501-3504, 2005 [PUBMED abstract]
  194. Poggioli R, Froud T, Baidal DA, Ferreira JV, Hafiz MM, Ricordi C, Gleich GJ, Alejandro R: Hypereosinophilia in an islet transplant recipient. Transplantation 79:853-854, 2005 [PUBMED Abstract]
  195. Rickels MR, Schutta MH, Markmann JF, Barker CF, Naji A, Teff KL: {beta}-Cell Function Following Human Islet Transplantation for Type 1 Diabetes. Diabetes 54:100-106, 2005 [PUBMED Abstract]
  196. Rickels MR, Schutta MH, Mueller R, Markmann JF, Barker CF, Naji A, Teff KL: Islet Cell Hormonal Responses to Hypoglycemia After Human Islet Transplantation for Type 1 Diabetes. Diabetes 54: 3205-3211, 2005 [PUBMED abstract]
  197. Ricordi C, Inverardi L, Kenyon NS, Goss J, Bertuzzi F, Alejandro R: Requirements for success in clinical islet transplantation. Transplantation 79:1298-1300, 2005 [PUBMED Abstract]
  198. Robertson RP, Tanaka Y, Takahashi H, Tran POT, Harmon JS. Prevention of oxidative stress by adenoviral overexpression of glutathione-related enzymes in pancreatic islets. Ann New York Acad Sci 2005 Jun;1043:513-20. [PUBMED Abstract]
Sabek OM, Fraga DW, Minoru O, McClaren JL, Gaber AO: Assessment of human islet viability using various mouse models. Transplant Proc. 37:3415-3416, 2005 [PUBMED abstract]
Sabek OM, Marshall DR, Minoru O, Fraga DW, Gaber AO: OP-142 gene expression profile of nonfunctional human pancreatic islets: predictors of transplant failure? Transplant Proc. 37:3441-3443, 2005 [PUBMED abstract]
Sweet IR, Gilbert M, Jensen R, Sabek O, Fraga DW, Gaber AO, Reems J: Glucose stimulation of cytochrome C reduction and oxygen consumption as assessment of human islet quality. Transplantation 80:1003-1011, 2005 [PUBMED abstract]
Todorov I, Nair I, Ferreri K, Rawson J, Kuroda A, Pascual M, Omori K, Valiente L, Orr C, Al-Abdullah I, Riggs A, Kandeel F, Mullen Y. Multipotent progenitor cells isolated from adult human pancreatic tissue. Transplant Proc. 2005 Oct;37(8):3420-1. [PUBMED abstract]
Wang W, Upshaw L, Strong DM, Robertson RP, Reems J: Increased oxygen consumption rates in response to high glucose detected by a novel oxygen biosensor system in non-human primate and human islets. J.Endocrinol. 185:445-455, 2005 [PUBMED abstract]
Witkowski P, Liu Z, Guo Q, Poumian-Ruiz E, Cernea S, Herold K, Hardy MA: Two-layer method in short-term pancreas preservation for successful islet isolation. Transplant Proc. 37:3398-3401, 2005 [PUBMED abstract]
  205. Yang Z, Chen M, Ellett JD, Carter JD, Brayman KL, Nadler JL. Inflammatory blockade improves human pancreatic islet function and viability. Am J Transplant 2005 Mar;5(3):475-83. [PUBMED abstract]
Zheng Q, Dai H, Merritt ME, Malloy C, Pan CY, Li W-H: A new class of macrocyclic lanthanide complexes for cell labeling and magnetic resonance imaging applications. J. Am. Chem. Soc., 2005, 127 (46), 16178-16188 27 October 2005
  207. Abdelli S, Ansite J, Roduit R, Borsello T, Matsumoto I, Sawada T, Allaman-Pillet N, Henry H, Beckmann JS, Hering BJ, Bonny C: Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes 53:2815-2823, 2004 [PUBMED Abstract]
  208. Brissova M, Fowler M, Wiebe P, Shostak A, Shiota M, Radhika A, Lin PC, Gannon M, Powers AC. Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Diabetes 2004 May;53(5):1318-25 [PUBMED Abstract]
  209. Cheng K, Fraga D, Zhang C, Kotb M, Gaber AO, Guntaka RV, Mahato RI: Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets. Gene Ther. 11:1105-1116, 2004 [PUBMED abstract]
  210. Cure P, Pileggi A, Froud T, Norris PM, Baidal DA, Cornejo A, Hafiz MM, Ponte G, Poggioli R, Yu J, Saab A, Selvaggi G, Ricordi C, Alejandro R: Alterations of the female reproductive system in recipients of islet grafts. Transplantation 78:1576-1581, 2004 [PUBMED Abstract]
Fenjves ES, Ochoa MS, Gay-Rabinstein C, Ricordi C, Curran MA: Retrovirally transferred genes inhibit apoptosis in an insulin-secreting cell line: implications for islet transplantation. Cell Transplant 2004; 13(5):489-96. [PUBMED]
  212. Gaber AO, Fraga D, Kotb M, Lo A, Sabek O, Latif K: Human islet graft function in NOD-SCID mice predicts clinical response in islet transplant recipients. Transplant Proc. 36:1108-1110, 2004 [PUBMED abstract]
  213. Hafiz MM, Poggioli R, Caulfield A, Messinger S, Geiger MC, Baidal DA, Froud T, Ferreira JV, Tzakis AG, Ricordi C, Alejandro R: Cytomegalovirus prevalence and transmission after islet allograft transplant in patients with type 1 diabetes mellitus. Am.J.Transplant 4:1697-1702, 2004 [PUBMED Abstract]
  214. Han D, Xu X, Baidal D, Leith J, Ricordi C, Alejandro R, Kenyon NS: Assessment of cytotoxic lymphocyte gene expression in the peripheral blood of human islet allograft recipients: elevation precedes clinical evidence of rejection. Diabetes 53:2281-2290, 2004 [PUBMED abstract]
  215. Holz GG. Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes 2004 Jan;53(1):5-13 [PUBMED abstract]
  216. Hope KM, Tran POT, Zhou H, Oseid E, LeRoy E, Robertson RP. Regulation of Alpha Cell Function by the Beta Cell in Isolated Human and Rat Islets Deprived of Glucose: the "Switch-off" Hypothesis. Diabetes 53:1488-1495, 2004. PMID: 15161753
  217. Kaido T, Yebra M, Cirulli V, Montgomery AM: Regulation of human beta-cell adhesion, motility, and insulin secretion by collagen IV and its receptor alpha1beta1. J Biol Chem 2004 Dec 17;279(51):53762-9. Epub 2004 Oct 12 6. [PUBMED abstract]
  218. Kaido T, Perez B, Yebra M, Hill J, Cirulli V, Hayek A, Montgomery AM: Alphav-integrin utilization in human beta-cell adhesion, spreading, and motility. J Biol Chem 2004 Apr 23;279(17):17731-7. Epub 2004 Feb 6. [PUBMED abstract]
  219. Klein D, Ribeiro MM, Mendoza V, Jayaraman S, Kenyon NS, Pileggi A, Molano RD, Inverardi L, Ricordi C, Pastori RL: Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets.  Biochem.Biophys.Res.Commun. 323:473-478, 2004 [PUBMED Abstract]
  220. Maffei A, Liu Z, Witkowski P, Moschella F, Del Pozzo G, Liu E, Herold K, Winchester RJ, Hardy MA, Harris PE: Identification of Tissue Restricted Transcripts in Human Islets. Endocrinology 2004 [PUBMED abstract]
  221. Matsumoto I, Sawada T, Nakano M, Sakai T, Liu B, Ansite JD, Zhang HJ, Kandaswamy R, Sutherland DE, Hering BJ: Improvement in Islet Yield from Obese Donors for Human Islet Transplants. Transplantation 78:880-885, 2004 [PUBMED Abstract]
  222. Matsumoto S, Tanaka K, Strong DM, Reems JA: Efficacy of Human Islet Isolation From the Tail Section of the Pancreas for the Possibility of Living Donor Islet Transplantation. Transplantation 78:839-843, 2004 [PUBMED Abstract]
  223. Narang AS, Cheng K, Henry J, Zhang C, Sabek O, Fraga D, Kotb M, Gaber AO, Mahato RI: Vascular endothelial growth factor gene delivery for revascularization in transplanted human islets. Pharm.Res. 21:15-25, 2004 [PUBMED abstract]
  224. Pileggi A, Fenjves ES, Klein D, Ricordi C, Pastori RL: Protecting pancreatic beta-cells. IUBMB.Life 56:387-394, 2004 [PUBMED Abstract]
  225. Ritzel RA, Hansen JB, Veldhuis JD, Butler PC. Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose. J Clin Endocrinol Metab 2004 Feb;89(2):795-805 [PUBMED Abstract]
  226. Rush BT, Fraga DW, Kotb MY, Sabek OM, Lo A, Gaber LW, Halim AB, Gaber AO: Preservation of human pancreatic islet in vivo function after 6-month culture in serum-free media. Transplantation 77:1147-1154, 2004 [PUBMED abstract]
  227. Sweet IR, Cook DL, DeJulio E, Wallen AR, Khalil G, Callis J, Reems J: Regulation of ATP/ADP in Pancreatic Islets. Diabetes 53:401-409, 2004 [PUBMED abstract]
Virostko J, Fowler M, Chen Z, Powers AC, Jansen ED: Factors influencing quantification of in vivo bioluminescence imaging: application to assessment of pancreatic islet transplants. Molecular Imaging 4:1-10, 2004 [PUBMED abstract]
  229. Wiseman AC, Gill RG: Current status of clinical islet transplantation: advances and obstacles. Curr Opin Endocrinol Diabetes. 11:98-103, 2004 [No Abstract Available]
  230. Zhang G, Matsumoto S, Hyon SH, Qualley SA, Upshaw L, Strong DM, Reems JA: Polyphenol, an Extract of Green Tea, Increases Culture Recovery Rates of Isolated Islets From Nonhuman Primate Pancreata and Marginal Grade Human Pancreata. Cell Transplantation 13:145-152 , 2004 [PUBMED abstract]
  231. Baidal DA, Froud T, Ferreira JV, Khan A, Alejandro R, Ricordi C: The bag method for islet cell infusion. Cell Transplant 12:809-813, 2003 [PUBMED abstract]
  232. Desai NM, Goss JA, Deng S, Wolf BA, Markmann E, Palanjian M, Shock AP, Feliciano S, Brunicardi FC, Barker CF, Naji A, Markmann JF: Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity? Transplantation 76:1623-1625, 2003 [PUBMED abstract]
Kandeel, Fouad; Smith, Craig V.; Todorov, Ivan; Mullen, Yoko: Advances in Islet Cell Biology: From Stem Cell Differentiation to Clinical Transplantation: Conference Report. Pancreas. 27(3):e63-e78, October 2003. [PUBMED]
  234. Mahato RI, Henry J, Narang AS, Sabek O, Fraga D, Kotb M, Gaber AO: Cationic lipid and polymer-based gene delivery to human pancreatic islets. Mol.Ther. 7:89-100, 2003 [PUBMED abstract]
  235. Markmann JF, Deng S, Huang X, Desai NM, Velidedeoglu EH, Lui C, Frank A, Markmann E, Palanjian M, Brayman K, Wolf B, Bell E, Vitamaniuk M, Doliba N, Matschinsky F, Barker CF, Naji A: Insulin independence following isolated islet transplantation and single islet infusions. Ann.Surg. 237:741-750, 2003 [PUBMED abstract]
  236. Markmann JF, Rosen M, Siegelman ES, Soulen MC, Deng S, Barker CF, Naji A: Magnetic resonance-defined periportal steatosis following intraportal islet transplantation: a functional footprint of islet graft survival? Diabetes 52:1591-1594, 2003 [PUBMED abstract]
  237. Ricordi C: Islet transplantation: a brave new world. Diabetes 52:1595-1603, 2003 [PUBMED abstract]
  238. Ritzel RA, Veldhuis JD, Butler PC: Glucose stimulates pulsatile insulin secretion from human pancreatic islets by increasing secretory burst mass; dose-response relationships. J Clin Endocrinol Metab 2003 Feb. 88(2):724-747. [PUBMED abstract]
  239. Ritzel RA, Butler PC: Replication increases beta cell vulnerability to human islet amyloid polypeptide induced apoptosis. Diabetes 2003. 52:1701-1708. [PUBMED abstract]
  240. Robertson RP, Kendall DM: Islet transplantation 2003: questions about its future. Curr Opin Endocrinol Diabetes 10:128-132, 2003.
  241. Song SH, Rhodes CJ, Veldhuis JD, Butler PC: Diazoxide attenuates glucose-induced defects in first phase insulin release and pulsatile insulin secretion in human islets. Endocrinology 2003 Aug. 144(8):3399-3405. [PUBMED abstract]
  242. Hering BJ, Matsumoto I, Sawada T, Nakano M, Sakai T, Kandaswamy R, Sutherland DE: Impact of two-layer pancreas preservation on islet isolation and transplantation. Transplantation 74:1813-1816, 2002 [PUBMED abstract]
  243. Knazek RA: The human pancreatic islet cell resource consortium. Diabetes Technol.Ther. 4:551-552, 2002 [PUBMED abstract]
  244. Matsumoto S, Qualley SA, Goel S, Hagman DK, Sweet IR, Poitout V, Strong M, Robertson RP, Reems JA: Effect of the two-layer [University of Wisconsin Solution (UW) / Perfluorochemical (PFC) Plus 02] method of pancreas preservation on human islet isolation as assessed by the Edmonton isolation protocol1 Transplantation 74(10):1414-9,2002. PMID: 12451242 [PUBMED abstract]
  245. Paty B, Ryan E, Shapiro AM, Lakey J, Robertson RP: Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence. Diabetes 51(12):3428-34, 2002. [PUBMED abstract]
  246. Robertson RP: Intrahepatically transplanted islets: Strangers in a strange land. J Clin Endocrinol Metab 87(12):5416-7, 2002. Full Text
  247. Song SH, Kjems L, Ritzel R, McIntyre SM, Johnson ML, Veldhuis JD, Butler PC: Pulsatile insulin secretion by human pancreatic islets. J Clin Endocrinol Metab 2002 Jan;87(1):213-21. [PUBMED abstract]
  248. Sweet IR, Khalil G, Wallen AR, Steedman M, Schenkman KA, Reems JA, Kahn SE, Callis JB: Continuous measurement of oxygen consumption by pancreatic islets. Diabetes Technol.Ther.4:661-672, 2002 [PUBMED abstract]
  249. Tanaka Y, Tran PO, Harmon J, Robertson RP: A role for glutathione peroxidase in protecting pancreatic B cells against oxidative stress in a model of glucose toxicity. Proc Natl Acad Sci USA 99(19):12363-8, 2002. PMID: 12218186 [PUBMED abstract]
  250. Wang DA, Narang AS, Kotb M, Gaber AO, Miller DD, Kim SW, Mahato RI: Novel branched poly(ethylenimine)-cholesterol water-soluble lipopolymers for gene delivery. Biomacromolecules. 3:1197-1207, 2002 [PUBMED abstract]
Abstracts, Presentations

  1. Costes S, Huang AC, Gurlo T, Daval M, Butler P: UCH-L1 deficiency may contribute to ß-cell defects in type 2 diabetes. Keystone Symposium "The Many Faces of Ubiquitin" Copper Mountain, Colorado, January 11-16, 2009 Abstract #124.
  2. Alonso, L, Vasavada, R, Wang, L, Pascoe, J, Mellado-Gil, J, Rosa, T, O’Donnell, C, Garcia-Ocana, A. Protein kinase C (PKC) z (zeta) activation is essential for glucose-mediated ß-cell proliferation.. First Annual Meeting of the Upper Midwest Islet Club, April 29-May 2, 2008. [Presentation]
  3. Alonso LC, Vasavada RC, Wang L, Pascoe J, Mellado-Gil JM, Rosa T, O'Donnell CP, Garcia-Ocaña A: Protein kinase C (PKC) Zeta activation is essential for glucose-mediated ß-cell proliferation. Proceedings of the Keystone Symposium "Islet and Beta Cell Development and Transplantation", 2008. [Presentation]
  4. Balamurugan AN, Velmurugan K and Pugazhenthi S. CREB-mediated protection of human islets from apoptosis in culture and after transplantation in streptozotocin-induced diabetic athymic nude mice. Keystone Symposium on Islet and Beta Cell Biology, Snowbird Utah, April 6-11 2008.
  5. Butler PC. Beta cell mass; a therapeutic target or the cards you are dealt? Keystone Symposium on Islet and Beta Cell Biology, Snowbird Utah, April 6-11 2008 Abstract #029.
  6. Fiaschi-Taesch N, Bigatel T, Sicara B, Takane KK, Stewart AF: Overexpression of cdk6, A human specific beta cell cdk, induces human beta cell proliferation and promotes engraftment and function of human islets. First Annual Meeting of the Upper Midwest Islet Club, April 29-May 2, 2008. [Presentation]
  7. Ho LT, Zebadua E, Kao P, Urrutia T, Orr C, Ferreri K, Kandeel F, Kuhtreiber W: Secretion of injury factors by human islets after isolation and hypoxia. The 8thAnnual Rachmiel Levine Diabetes and Obesity Symposium January13-16, 2008.
  8. Hughes KJ, Corbett JA: Repair of Pancreatic beta-cells from cytokine-mediated DNA damage. First Annual Meeting of the Upper Midwest Islet Club, April 29-May 2, 2008. [Poster]
  9. Iglesias, I Bentsi-Barnes, K, Umeadi, C, Brown, L, Wert, D, Spalla, C, Kandeel, F, Al-Abdullah, IH. Flow and laser scanning cytometry analysis of human pancreatic islets. The 8th Annual Rachmiel Levine Diabetes and Obesity Symposium January 13-16, 2008.
  10. Kaddis, J, Dajun, Q, Olack, B, Cravens, J, Antler, M, Ruel, N, Hanson, M, Papas, K, Contreras, J, Fernanadez, L, Niland, J. Temperature and Pressure changes during islet transport using a standardized shipping container: A study by the National Islet Cell Resource Center Consortium. The 8th Annual Rachmiel Levine Diabetes and Obesity Symposium January 13-16, 2008.
  11. Kaestner KH. Using functional genomics to identify targets for beta-cell expansion. Keystone Symposium on Islet and Beta Cell Biology, Snowbird Utah, April 6-11 2008 Abstract #005.
  12. Lavine, JA, Raess, PW, Davis, DB, Presley, BK, Schueler, KL, Fernandez, LA. Overexpression of cholecystokinin in isolated human islets stimulates beta cell proliferation. First Annual Meeting of the Upper Midwest Islet Club, April 29-May 2, 2008. [Presentation]
  13. Lei, X, Zhang, S, Ramanadam, S. Ceramides and their role in ER stress-induced beta cell death. Implications for T1DM. First Annual Meeting of the Upper Midwest Islet Club, April 29-May 2, 2008.
  14. Liu H, Remedi MS, Pappan KL, Kwon G, Rohatgi N, Marshall CA, McDaniel ML. Both Glycogen Synthase Kinase-3 (GSK-3) and Mammalian Target of Rapamycin (mTOR) Pathways Contribute to DNA Synthesis, Cell Cycle Progression and Proliferation in Human Islets. Washington University in St. Louis Diabetes Research Training Center Diabetes Day Symposium Nov 14, 2008. [Poster]
  15. Luo L, Fang X, Ricordi C, Luo J. Human Islet Longevity: A New Approach with Allogeneic Bone Marrow. 2008 Diabetes 57:Suppl.1 1596-P, A446
  16. Mellado-Gil JM, Rosa T, Gonzalez-Pertusa JA, Demirci C, Garcia-Ocaña A: Hepatocyte growth factor (HGF) receptor, c-Met is dispensable for normal β-cell growth and function but essential for β-cell survival and proliferation in an animal model of type 1 diabetes. Proceedings of the Keystone Symposium "Islet and Beta Cell Development and Transplantation", 2008. [Presentation]
  17. Nair, I, Todorov, I, Rawson, J, Shintaku, J, Valiente, L, Omori, K, Kandeel, F, Mullen, Y. Islet grading using image analysis A novel technique for islet quality assessment. The 8th Annual Rachmiel Levine Diabetes and Obesity Symposium January 13-16, 2008.
  18. Niland J: NIH funded Islet Resource Centers (ICR) program: Update. The 8thAnnual Rachmiel Levine Diabetes and Obesity Symposium January13-16, 2008.
  19. Nunemaker CS, Runpei WU, Kaiwen MA, Chakrabarti SK, Nadler JL: 12-Lipoxygenase Products Reduce Insulin Secretion and Viability in Human Islets: A Possible Role of p38 MAPK. Presented to American Diabetes Association, 2008. Abstract #1562-P.
  20. Ogihara, T, Garmey, JC, Chuang, JC, Repa, JJ, Ketchum, RJ, Brayman, KL, Mirmira, RG, Evans-Molina, Carmella. Liver X receptor agonism augments glucose-stimulated insulin transcription and secretion in human islets. First Annual Meeting of the Upper Midwest Islet Club, April 29-May 2, 2008. [Presentation]
  21. Omori, K Nair, Indu, Valiente, Luis, Todorov, I, Kanseel, F, Mullen, Y. Validation of conventional manual counting of human islets by semi-automated digital image analysis. The 8th Annual Rachmiel Levine Diabetes and Obesity Symposium January 13-16, 2008.
  22. Rawson J, Kandeel F, Mullen Y: An inherent problem with the non-diabetic NODscid mouse as an in vivo model for isolated islet quality. The 8th Annual Rachmiel Levine Diabetes and Obesity Symposium January 13-16, 2008.
  23. Shintaku, J, Omori, K, Rawson, J Kandeel, F, Mullen, Y. Positive correlation between ATP/ADP Ratio and glucose-stimulated insulin release of cultured human islets. The 8th Annual Rachmiel Levine Diabetes and Obesity Symposium January 13-16, 2008.
  24. Stewart, AF. Molecular Control of the cell cycle in pancreatic beta cells. The 8th Annual Rachmiel Levine Diabetes and Obesity Symposium January 13-16, 2008.
  25. Thurmond DC. Regulation of second-phase insulin secretion by Cdc-42, Syntaxin 4 and Munc18c. Keystone Symposium on Islet and Beta Cell Biology, Snowbird Utah, April 6-11 2008 Abstract #018.
  26. Weir, G. The fate of transplanted islets exposed to hyperglycemia. The 8th Annual Rachmiel Levine Diabetes and Obesity Symposium January 13-16, 2008.
  27. Al-sayed, M, Al-Abdullah, I., Omori, K, Williams, B, Todorov, I Ferrir, K, Ipp, E, Mullen, Y, Smith, Craig, Kandeel, F. Improved graft survival following islet transplantation using higher sirolimus levels. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
Asari S, Itakura S, Rawson J, Ito T, Todorov I, Nair I, Liu CP, Kandeel F, Mullen Y: Intervention of autoimmunity in NOD mice by co-transplantation of allogeneic bone marrow cell and mesenchymal stem cells. Joint Conference CTS-IPITA-IXA September 15-20, 2007.
  29. Avgoustiniatos, E, Hering B, Rozak, P, Wilson, J, Tempelman, L, Papas, K. Commercially available gas-permeable bags may not prevent anoxia in cultured or shipped islets. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  30. Bansal-Pakala, P, Hire, K, Clemmings, S, Hering, B.HOKT3gamma Ala, Ala induces higher treg frequencies in islet transplant patients correlating with long-term graft survival. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  31. Bansal-Pakala, P, Hire, K, Sullivan, N, Ngo, Diem, Parkey, J, Hering, B. Long-term islet allograft survival with increased CD4+CD25+FoxP3+Tregs in type 1 diabetic recipients. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  232 Bigatel TA, Cozar-Castellano I, Velasquez S, Harb G, Fiaschi-Taesch N, Selk K, Takane KK, Stewart AF. Comprehensive Comparative Cell Cycle Analysis Reveals Critical Differences Between Human and Murine Beta Cell Cycle Regulation: Human Islets Contain Cdk-6 But Lack Cdk-4. The 67th Annual Scientific Sessions of the American Diabetes Association, June 22-26 2007.
  33. Bonner-Weir, S. Beta cell regeneration. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  34. Danobeitia, J, Greenwood, K, Vijayan, Am Hanson, M, Odorico, J, Fernandez, L. Quantitative and qualitative comparison of the performance of Serva NB1 collagenase and neutral protease with Liberase HI in the isolation of human pancreatic islets. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  35. Fernandez, L. Pancreas donation after cardiac death. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  36. Fu Z, Liu D. Phytochemical Genistein Promotes Beta Cell Survival, Insulin Secretory Function and Ameliorates Hyperglycemia in Streptozotocin Induced Diabetic Mice. The 67th Annual Scientific Sessions of the American Diabetes Association, June 22-26 2007.
  37. Garcia-Ocaña A, Sipula D, Takane K, Bottino R, Trucco M, Vasavada RC. Parathyroid hormone-related protein (PTHrP) is a mitogen for human beta cells through the PTH/PTHrP receptor. Proceedings of the 89th Meeting of the Endocrine Society, 2007.
  38. Hanson, M, Armann, B, Steffen, A, Sperger, J, Hullet, D, Odorico, J, D'Alessandro, A, Sollinger, H, Fernandez, L. Evaluation of islet quality from donation after cardiac death using a novel extended quality control assessment program. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  39. Hanson, M, Hullet, D, Sperger, J, Greenwood, K, Vijayan, A, Odorico, J, Fernandez. L. Reducing islet transplant primary graft non-function through implementation of an extended quality control assessment program. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  40. Hering, B, Parkey, J, Kandaswamy, R, Jevne, R, Snead, D, Lervk, B, Harmon, J, Tanaka, T,Yonekawa, Y Matsumoto, S. Analysis of long-term silet allograft function in recipients given depleting T-cell antibodies for induction immunosuppression. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  41. Ichii H, Yamamoto T, Sakuma Y, Miki A, Rodriguez R, Inverardi L, Ricordi C. The effect of non-endocrine cells on islet potency: Comparison between ADP/ATP ratio and p-cell fractional viability. American Journal of Transplantation, 7:205-206 227 Suppl. 2 May 2007.
  42. Inverardi, L. Islet cytoprotection. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  43. Linetsky, E. Regulation challenges in manufacturing of pancreatic islets. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  44. Luo L. Allogeneic Bone Marrow Repair Human Islet Damage: A New Approach In Ex Vivo. Invited Lecture, Stem Cells For Diabetes Therapy In Human Islet. Cellutions Summit August 16-19 2007, Boston, Massachusetts.
  45. Naji, A. Targeting beta cells. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  46. Oberholzer, J. The one step density gradient for human islet purification. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  47. Oberholzer, J. Islet cells. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
Omori K, Shintaku J, Rawson J, Todorov I, Nair I, Al-Abdullah I, Higgins L, Medicherla S, Kandeel F, Mullen Y: p38 mitogen activated protein kinase inhibitor improves the quality of cultured human islets. Joint Meeting of the International Xenotransplantation, the International Pancreas and Islet Transplantation Association, and the Cell Transplantation Society, Sept. 2007, 14, p420 #307.9
  49. Omori K, Shintaku J, Rawson J, Todorov I, Nair I, Al-Abdullah I, Higgins L: P38 mitogen activated protein kinase inhibitor (p38IH) improves the quality of cultured human islets. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  50. Papas, K. New approaches to pancreas preservation. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  51. Papas, K. New equipment for islet culture and shipment. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  52. Pappan KL, Liu H, Remedi MS, Marshall CA, Kwon G, McDaniel ML: Glycogen synthase kinase (GSK-3) signaling to mammalian target of rapamycin (mTOR) regulates DNA synthesis and cell cycle progression in rodent and human islets. Diabetes 2007 56 S1 1755-P ADA 67th Scientific Sessions. [Abstract]
  53. Rickels, M, Mueller, R, Markmann, J, Naji, A. Effect of GLP-1 on β- and α cell function in isolated islet and whole pancreas transplant recipients. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  54. Ricordi, C. Enzymes for human isolation - How I do it. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  55. Ricordi, C. New equipment for islet processing. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  56. Salehi, P, Barbaro, B, Wang, Y, Qi, M, Gangemi, A, Kuechle, J, Hansen, M, Benedetti, E, Mage, R, Oberholzer, J. Improved human pancreatic islet purification using the refined UIC-UB density gradient. 2007 Joint Conference CTS-IPITA-IXA September 15-20, 2007. [Presentation]
  57. Klein D, Barbe-Tuana F, Berman-Weinberg D, Kenyon NS, Ricordi C, Pastori RL. CD40-CD40L Interaction Activates Pro-Inflamatory Pathways In Pancreatic Islets. World Transplant Congress Boston MA, July 2006.
  58. Zhang W, Liu D. Genistein Induces Pancreatic Beta-Cell Proliferation through the Cyclic AMP Dependent Protein Kinase and MEK/ERK Signaling Pathways. The 66th Annual Scientific Sessions of the American Diabetes Association, June 9-13 2006.
  59. Barbe-Tuana F, Klein D, Ichii H, Escalona M, Berman-Weinberg D, Kenyon NS, Ricordi C, Pastori R.L. Proinflammatory Pathway Activation through CD40 in Human and Non Human Primate Islet Cells. Late-Breaking Research Abstracts. American Diabetes Association. 65th Scientific Sessions, San Diego, California, June 2005
  60. Barbe-Tuana, F., Klein D., Pugliese, A., Ichii, H., Gonzalez, M., Molano, R.D., Ricordi, C., Pastori, R.L. Expression of CD40 in pancreatic beta cells. The Cell Transplant Society 7th International Congress November 2004, Boston, USA
  61. Fenjves ES, Gay-Rabinstein C, Ochoa MS, et al. Human pancreatic islets genetically engineered using a bicistronic lentiviral vector: Implications for islet transplantation. Presented to Cell Transplantation Society, Boston MA, November 2004.
  62. Fenjves ES, Ochoa MS, Gay-Rabinstein C, et al. Delivery of two genes to human pancreatic islets using a bicistronic feline immunodeficiency viral vector improves islet viability; implications for enhancing islet transplantation. Presented to American Diabetes Association, 64th Scientific Sessions, Orlando Florida, June 4-8 2004.
  63. Fenjves ES, Ochoa MS, Gay-Rabinstein C, et al. Transduction of human pancreatic islets using a bicistronic feline immunodeficiency viral vector; implications for islet transplantation. Presented to American Transplant Congress, Boston MA, May14-19 2004.
  64. Mendoza V, Klein D, Ichii H, Ricordi C, and Pastori, RL. Protection of islets in culture by delivery of oxygen binding neuroglobin via protein transduction. XX International Congress of the Transplantation Society, Vienna September 2004.
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