ICR Steering Committee       The ICR is an interactive group of laboratories whose primary purpose is to supply investigators with clinical grade islets for ICR-approved studies. The Steering Committee (SC) will oversee the general functions of the ICR, based on the present Policy and Procedures document, and evaluate the clinical and scientific merit of submitted applications. The SC will also determine which ICR facility will produce the islets for each ICR-approved request. After distribution of the islets, the ICR SC will become informed of, and will monitor, serious adverse events involving ICR-supported protocols when the clinical investigator reports them to local and Federal oversight groups in accordance with institutional, state, and Federal guidelines. The SC will not serve as a Data and Safety Monitoring Board for individual transplantation protocols. The ICR Steering Committee is comprised of the chairman, the Administrative and Bioinformatics Coordinating Center (ABCC) Director, 10 ICR directors, 2 outside experts, a Food and Drug Administration (FDA) representative, a National Institutes of Diabetes and Digestive Kidney Diseases (NIDDK) representative, a Juvenile Diabetes Research Foundation International (JDRFI) representative, and a National Center for Research Resources (NCRR) representative.

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